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About Titanium Dioxide. Titanium Dioxide, a white crystalline powder, represents the natural oxide of titanium, with its primary occurrence observed specifically in rutile ores. This titanium compound holds remarkable significance in various technological realms, functioning as a commodity chemical extensively harnessed across diverse industries. In actuality, a substantial majority of titanium ores undergo processing procedures to yield Titanium Dioxide, consequently establishing its unrivaled status as the most extensively utilized titanium-based substance on a global scale.

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The report also covers a detailed analysis of the project economics for setting up a lithopone manufacturing plant. This includes the analysis and detailed understanding of capital expenditure (CapEx), operating expenditure (OpEx), income projections, taxation, depreciation, liquidity analysis, profitability analysis, payback period, NPV, uncertainty analysis, and sensitivity analysis. Furthermore, the report also provides a detailed analysis of the regulatory procedures and approvals, information related to financial assistance, along with a comprehensive list of certifications required for setting up a lithopone manufacturing plant.
 

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Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

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The conventional surface treatment methods of titanium alloy include glow discharge plasma deposition, oxygen ion implantation, hydrogen peroxide treatment, thermal oxidation, sol-gel method, anodic oxidation, microarc oxidation, laser alloying, and pulsed laser deposition. These methods have different characteristics and are applied in different fields. Glow discharge plasma deposition can get a clean surface, and the thickness of the oxide film obtained is 2 nm to 150 nm [28]. The oxide film obtained from oxygen ion implantation is thicker, about several microns [914]. Hydrogen peroxide treatment of titanium alloy surface is a process of chemical dissolution and oxidation [1516]. The dense part of the oxide film is less than 5 nm [1721]. The oxide film generated from the thermal oxidation method has a porous structure, and its thickness is commonly about 10-20 μm [2225]. The oxide film from the sol-gel method is rich in Ti-OH, a composition that could induce apatite nucleation and improve the combining of implants and bone. It has a thickness of less than 10 μm [2628]. Applied with the anodic oxidation method, the surface can generate a porous oxide film of 10 μm to 20 μm thickness [2931]. Similarly, the oxide film generated from the microarc oxidation method is also porous and has a thickness of 10 μm to 20 μm [3233].

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